Exploitation of glycosylation in enveloped virus pathobiology
Identifieur interne : 000B43 ( Main/Exploration ); précédent : 000B42; suivant : 000B44Exploitation of glycosylation in enveloped virus pathobiology
Auteurs : Yasunori Watanabe [Royaume-Uni] ; Thomas A. Bowden [Royaume-Uni] ; Ian A. Wilson [États-Unis] ; Max Crispin [Royaume-Uni]Source :
- Biochimica et Biophysica Acta. General Subjects [ 0304-4165 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Virus.
- métabolisme : Glycoprotéines, Polyosides, Virus.
- Glycosylation, Humains, Interactions hôte-pathogène, Mimétisme moléculaire, Phénomènes physiologiques viraux, Pliage des protéines, Transport de protéines, Échappement immunitaire.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Glycoproteins, Polysaccharides.
- immunology : Viruses.
- metabolism : Viruses.
- Glycosylation, Host-Pathogen Interactions, Humans, Immune Evasion, Molecular Mimicry, Protein Folding, Protein Transport, Virus Physiological Phenomena.
Abstract
Glycosylation is a ubiquitous post-translational modification responsible for a multitude of crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to glycosylate their own proteins during replication. Viral envelope proteins from a variety of human pathogens including HIV-1, influenza virus, Lassa virus, SARS, Zika virus, dengue virus, and Ebola virus have evolved to be extensively glycosylated. These host-cell derived glycans facilitate diverse structural and functional roles during the viral life-cycle, ranging from immune evasion by glycan shielding to enhancement of immune cell infection. In this review, we highlight the imperative and auxiliary roles glycans play, and how specific oligosaccharide structures facilitate these functions during viral pathogenesis. We discuss the growing efforts to exploit viral glycobiology in the development of anti-viral vaccines and therapies.
Url:
DOI: 10.1016/j.bbagen.2019.05.012
PubMed: 31121217
PubMed Central: 6686077
Affiliations:
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General Subjects</title><idno type="ISSN">0304-4165</idno><idno type="eISSN">1872-8006</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Glycoproteins (metabolism)</term><term>Glycosylation</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Immune Evasion</term><term>Molecular Mimicry</term><term>Polysaccharides (metabolism)</term><term>Protein Folding</term><term>Protein Transport</term><term>Virus Physiological Phenomena</term><term>Viruses (immunology)</term><term>Viruses (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Glycoprotéines (métabolisme)</term><term>Glycosylation</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mimétisme moléculaire</term><term>Phénomènes physiologiques viraux</term><term>Pliage des protéines</term><term>Polyosides (métabolisme)</term><term>Transport de protéines</term><term>Virus (immunologie)</term><term>Virus (métabolisme)</term><term>Échappement immunitaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glycoproteins</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéines</term><term>Polyosides</term><term>Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Glycosylation</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Immune Evasion</term><term>Molecular Mimicry</term><term>Protein Folding</term><term>Protein Transport</term><term>Virus Physiological Phenomena</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Glycosylation</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mimétisme moléculaire</term><term>Phénomènes physiologiques viraux</term><term>Pliage des protéines</term><term>Transport de protéines</term><term>Échappement immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Glycosylation is a ubiquitous post-translational modification responsible for a multitude of crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to glycosylate their own proteins during replication. Viral envelope proteins from a variety of human pathogens including HIV-1, influenza virus, Lassa virus, SARS, Zika virus, dengue virus, and Ebola virus have evolved to be extensively glycosylated. These host-cell derived glycans facilitate diverse structural and functional roles during the viral life-cycle, ranging from immune evasion by glycan shielding to enhancement of immune cell infection. In this review, we highlight the imperative and auxiliary roles glycans play, and how specific oligosaccharide structures facilitate these functions during viral pathogenesis. We discuss the growing efforts to exploit viral glycobiology in the development of anti-viral vaccines and therapies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jones, K E" uniqKey="Jones K">K.E. 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Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Watanabe, Yasunori" sort="Watanabe, Yasunori" uniqKey="Watanabe Y" first="Yasunori" last="Watanabe">Yasunori Watanabe</name></noRegion><name sortKey="Bowden, Thomas A" sort="Bowden, Thomas A" uniqKey="Bowden T" first="Thomas A." last="Bowden">Thomas A. Bowden</name><name sortKey="Crispin, Max" sort="Crispin, Max" uniqKey="Crispin M" first="Max" last="Crispin">Max Crispin</name><name sortKey="Watanabe, Yasunori" sort="Watanabe, Yasunori" uniqKey="Watanabe Y" first="Yasunori" last="Watanabe">Yasunori Watanabe</name><name sortKey="Watanabe, Yasunori" sort="Watanabe, Yasunori" uniqKey="Watanabe Y" first="Yasunori" last="Watanabe">Yasunori Watanabe</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name></region><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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